The purpose of this study was to develop a Thai Smoking Cessation Quality of Life Assessment Instrument (TSCQoL) and examine the validity and reliability of this measure. This methodological research involves 3 processes: (1) instrument development, (2) expert review of the instrument, and (3) testing of the instrument. The draft TSCQoL was developed by using literature review, SF-36 Thai version and unstructured interviews with 16 smokers, 8 ex-smokers and 5 healthcare workers. The initial 95-item instrument, comprised two aspects was generated, 71 items were intended to quantify the impact of smoking cessation on perceived functioning and well-being in adults (HRQoL aspect) and 24 items were intended to assess the inherent burden associated with the consumption of smoking cessation pharmacotherapies (PTRQoL aspect). Five-point Likert scale was used as response choice of each item. Following content validation by expert review panels, the draft TSCQoL was pre-tested in a sample of 20 adults and large scale-tested in a sample of 431 adults (smokers and ex-smokers) for HRQoL aspect and 78 adults (smokers and ex-smokers receiving pharmacotherapies) for PTRQoL aspect. For psychometric properties, exploratory factor analysis with item analysis was used to examine the construct validity and reliability of HRQoL aspect whereas item analysis was used to explore the reliability for PTRQoL aspect. Known group validity was used to support the evidence of construct validity of both revised aspects. The results indicated that both aspects had content validity, construct validity and high internal consistency reliability. The HRQoL aspect was revised to 36 items with overall coefficient alpha 0.93. Principal axis factoring with oblique (promax) revealed four subscales for HRQoL aspect: (1) general well being (18 items), (2) satisfaction (8 items), (3) self-control (4 items), and (4) mental and emotional problems (6 items). Mann-Whitney-U test revealed that ex-smokers who had been abstinent for more than or equal to 3 months reported significantly higher quality of life scores than smokers on four subscales (p < 0.02), representing the construct validity of HRQoL aspect. The PTRQoL aspect was retained at 24 items, comprised two subscales: (1) psychosocial consequences (8 items), and (2) negative consequences (16 items) with overall coefficient alpha 0.83. Mann-Whitney-U test also confirmed the construct validity of PTRQoL aspect by presented that participants receiving bupropion SR reported significantly higher pharmaceutical related quality of life scores than participants receiving nicotine gum on psychosocial consequences subscale (p=0.03). These findings identify preliminary evidence for the validity and reliability of the TSCQoL instrument

M.Sc. in Pharm จุฬาลงกรณ์มหาวิทยาลัย ปี 2546

Evaluation, of, Thailand, Quality, Smoking, cessation, life, --, programs