Objectives: This study aimed to validate a health-related quality of life instrument for epilepsy (HQOL) in Thais with epilepsy. Methods: The Liverpool HQOL questionnaire, the National Hospital Seizure Severity Scale (NHS) and the Epilepsy Psycho-Social Effect Scale (EPS) were translated into Thai, back translated and then applied to 129 people with epilepsy attending neurological clinics at 4 sites located in the Central area, the South and the North of Thailand. The questionnaire was composed of 6 parts, namely: the Adverse Drug Events Scale, the Rosenberg Self-esteem Scale, the Life Fulfillment Scale, the Hospital Anxiety and Depression Scale (HADS), the NHS and the EPS. Reliability, construct and discriminant validities were analyzed. Results: The reliability test for each of the questionnaires was good to excellent. The construct validity of the HADS was confirmed by the other measures. Discriminant validity showed that the questionnaire could distinguish patients with good health status perception from those with poor health status, and could discriminate patients with more frequent seizure attacks from those with less frequent seizures. Conclusions: The Thai version of the HQOL instrument is a reliable and valid measure of quality of life of Thai people with epilepsy.

Neurological Journal of South East Asia ปี 2546, December ปีที่: 8 ฉบับที่ หน้า 103-107