This is a descriptive study that evaluates the quality of live (QOL) of road accident head-injured patients after craniotomy. It investigates the relationship between the independent variables of demographic data, health, and social and economics and four aspects of participants’ QOL, satisfaction, perception, health, and social and economics. The ninety participants in the study were patients with head injuries resulting from involvement in road accidents who were attending a neurological clinic at Sapasithiprasong Hospital, Ubon Ratchathani, Thailand. Data was collected by participants completing a questionnaire. Results showed most participants had high QOL after craniotomy in satisfaction, life perception, health, and social and economics. There were negative relationships between QOL and duration of hospital stay, medical complications, and levels of disability. The study indicates the need for efficient postoperative care of head-injured patients to return them quickly to their daily lives.