Postoperative nausea and vomiting (PONV) is one of the most frequent complications after general anesthesia in the patient who underwent breast mass surgery. The optimal strategy to prevent PONV remains unclear. This study is double-blinded randomized controlled trial to compared PONV of two anesthesia techniques; inhalation anesthesia with sevoflurane and total intravenous aneathesia with propofol after breast mass surgery in Nakhonphanom hospital. Method: Eighty four patients ASA physical status I – II who undergoing elective breast mass surgery were randomly allocated to receive either inhalation anesthesia with sevoflurane (IA group) and total intravenous aneathesia with propofol (TIVA  group).Result: Patients in TIVA group had  lower  incidence  of  PONV  comparison  to  those in IA group (26.2% vs 38.1%). The cost of anesthesia was significantly lower in TIVA group than IA group (2,666 ฿ vs 2,072 ฿). Sevoflurane was fixed cost at 450 baht per hour. Conclusion Total intravenous anesthesia with propofol reduced the incidence of PONV compared to inhalation anesthesia with sevoflurane.