Randomized, controlled trial testing the effectiveness and safety of 2.5% and 5% benzoyl peroxide for the treatment of pitted keratolysis
Charssri Leeyaphan, Pichaya Limphoka, Rungsima Kiratiwongwan, Punyawee Ongsri, สุมนัส บุณยะรัตเวช*
Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Email: consultskin@yahoo.com
บทคัดย่อ

Background: The appropriate dosage and duration of topical benzoyl peroxide gel (BP) treatment of pitted keratolysis (PK) is controversial.

Objective: To compare the effectiveness and safety of topical 2.5% and 5% BP for the treatment of PK.

Materials and methods: This randomized, controlled trial was conducted at Chumpol Naval Rating School, Chonburi, Thailand. Naval rating cadets with PK were randomly assigned to either a 2.5% or a 5% BP group and were requested to apply the related medication on each sole once daily, for 2 weeks.

Results: All 42 and 47 participants who were treated with 2.5% and 5% BP, respectively, were included in the later analysis. Self-evaluation of the foot odor level using a visual analog scale (VAS) showed significant decreases for both groups (p<.001). The pitted lesions were evaluated by dermatologists and found to have improved in the 2.5% and 5% BP groups (69.0% versus 63.8%, respectively; p=.457). Side effects did not statistically differ between the two groups (p>.05).

Conclusions: Either 2.5% or 5% BP can be used for the treatment of PK and foot malodor. Due to the similarities in their efficacies and side effects, the use of 2.5% BP may be preferable.

 
ที่มา
The Journal of Dermatological Treatment ปี 2564, November ปีที่: 32 ฉบับที่ 7 หน้า 851-854
คำสำคัญ
Pitted keratolysis, benzoyl peroxide, foot odor