Background: Brugada syndrome (BrS) is a rare cardiac arrhythmic syndrome which can increase the risk of sudden cardiac death in patients without structural heart disease. BrS may affect patients’ quality of life due to

long-term follow-up.

Objective: To identify the quality of life and related factors in patients with BrS.

Methods: Twenty-nine patients with BrS from King Chulalongkorn Memorial Hospital were recruited between August 2019 to April 2020. We collected demographic data, evaluated depression/anxiety with Thai-HADS test, and administered cognitive tests and the quality of life questionnaires (MacNew and SF-36). Descriptive and multiple linear regression were used to analyze the data.

Results: There were 28 male and 1 female subjects. The average age was 45.2 + 13.8 years old. The result of MacNew questionnaire score was 5.6 + 0.8. For SF-36, the physical component score was 49.8 + 6.4 and mental component score was 52.9 + 6.3. The score of anxiety and depression from HADS was 4.4 + 2.9 and 3.3 + 3.3, respectively. For the cognitive test, the following results were observed; the Grooved Pegboard on dominant (78.4 + 27.9 seconds) and non-dominant (84.5 + 26.0 seconds), Trail A (53.7 + 20.7 seconds) and B (181.0 + 80.9 seconds), and memory tests (Word List Memory 21.0 + 4.4 words; recall 7.2 + 2.6 words; and recognition 9.6 + 1.0 words). From multiple regression analysis, only the anxiety score from HADS had a statistically significant impact on the quality of life.