Background: Intertrigo is a common skin problem. Although there was no standard treatment due to few clinical studies, topical corticosteroids, and drying agents such as talcum are usually used to treat intertrigo, and the side effects of these agents should be monitoring.

Objective: To compare the efficacy between cream containing spent grain wax, shea butter, Argania spinosa kernel oil, Tapioca starch, and 1% hydrocortisone cream for the treatment and prevention of intertrigo.

Materials and Methods: Fifty-eight lesions from 18 intertrigo patients were randomized into two groups, HCC group, which is the 1% hydrocortisone cream and STIMU-TEX AS group, which is the combination cream of spent grain wax, shea butter, Argania spinosa kernel oil, and tapioca starch. The evaluations were performed at baseline, the first week, the second week, and the fourth week via scoring of skin redness, pruritus, excoriation, Dermatology Life Quality Index (DLQI), and patient satisfaction. The adverse events were also recorded.

Results: All participants completed the protocol. At the end of the study, 27 of 29 lesions were completely cured in the HCC group, and 25 of 29 lesions cured in the STIMU-TEX AS group. Although the number of complete remissions of the STIMU-TEX AS group was inferior to the HCC group, it was not statistically significant. There was no relapse within two weeks after completing the treatment.

Conclusion: The outcomes showed no statistically significant difference between both groups; thus, the cream may be considered as an alternative treatment and prevention of intertrigo.