Objective: To determine health related quality of life [QoL] of patients diagnosed with cardiovascular disease [CVD] among smokers and non-smokers in Thailand.

Materials and Methods: The questionnaire using ED-5D was conducted in patients with CVD at Ramathibodi Hospital between June 1, 2016 and May 31, 2017.

Results: Four hundred and twenty patients completed the questionnaires. The mean utility score of Thai CVD patients were 0.73 (SD ±0.16), 0.69 (SD ±0.22), and 0.72 (SD ±0.23) for never smoked, currently smoked, and used to smoked patients, respectively.

Conclusion: The cross-sectional study showed different QoL of the CVD patients among smoker and non-smokers in Thailand although there was no significant. Further study should address predictors and mechanisms acting on QoL in these group of patients.