Randomized Study of Antiinflammatory and Immune-Modulatory Effects of Enteral Immunonutrition During Concurrent Chemoradiotherapy for Esophageal Cancer
Somkiat Sunpaweravong*, Puttisak Puttawibul, ศักดิ์ชาย เรืองสิน, Supparerk Laohawiriyakamol, ภัทรพิมพ์ สรรพวีรวงศ์, ดวงใจ แสงถวัลย์, Jintana Pradutkanchana, Ponpis Raungkhajorn, Alan Brockman
Department of Surgery, Faculty of Medicine , Prince of Songkla University , Songkla , Thailand.
บทคัดย่อ
Concurrent Chemoradiotherapy (CCRT) induces toxicities from inflammation and immunological suppression. Omega-3 fatty acids, glutamine, and arginine are therapeutic factors that can attenuate such inflammation and promote cellular immunity. The question is whether immunonutrition (IN) during CCRT reduces inflammation and improves the immune function in patients with esophageal squamous cell carcinoma (ESCC). Seventy-one locally advanced ESCC patients being treated with CCRT (5-FU and cisplatin) were randomized into 2 groups. The IN group received a combination of omega-3 fatty acids, glutamine, and arginine , whereas the control group received standard formula. The levels of C-reactive protein (CRP), tumor necrosis factor (TNF), interferon-gamma (IFN), interleukin (IL-6, IL-10), CD3, CD4, CD8, white blood cells, neutrophils, and total lymphocytes were measured before and during treatment. The levels of CRP (p = 0.001) and TNF (p = 0.014) increased more during treatment in the control group than the treatment group, whereas IFN, IL-6, and IL-10 were similar but not significantly. CD3, CD4, CD8, white blood cells, neutrophils, and total lymphocytes decreased more in the control group than in the treatment group, but not significantly. Enteral IN during CCRT reduced the increase of inflammatory cytokine levels.
 
ที่มา
Nutrition and Cancer ปี 2557, ปีที่: 66 ฉบับที่ 1 หน้า 1-5