Objectives: To compare complete abortion rate, duration of abortion, and side effects
between sublingual and vaginal misoprostol.

Materials and Methods: Sixty pregnant women up to 12 weeks of gestation diagnosed
with early pregnancy failure were randomized to receive 600 μg sublingual misoprostal or 600 μg vaginal misoprostol. If the abortion did not occur, the repeated medication would be done every 3 hours in case of the sublingual route or every 6 hours in case of the vaginal route, for maximum of three doses in totally.

Results: There was no difference in the effects on abortion , duration of abortion time and
the side effects between two groups (p > 0.05). Diarrhea was common in the sublingual group. The
side effects of both groups were similar which included abdominal pain, nausea, fever, heavy
bleeding, headache and pelvic infection.

Conclusion: Sublingual misoprostal was as effective as vaginal misoprostal. Most side
effects of both groups were similar except that diarrhea was more than in sublingual group.