There are many alternatives to control postoperative pain. Using local anesthesia to supplement general anesthesia is one of the current interesting techniques. Our objective was to determine whether postincisional wound infiltration with 0.25% bupivacaine provided postoperative pain control better than without local anesthetic infiltration. A prospective, randomized, double-blind controlled trial was done in 28 ASA class I and II women scheduled to undergo abdominal hysterectomy who were randomized into group I (treatment) or group II (control). Group I (treatment) received 30 ml of 0.25% bupivacaine infiltrated at the wound immediately before closure. Group II (control) received no local anesthetic infiltration. Pain assessment using visual analogue scales, time to first analgesic requirement, and postoperative analgesic consumption. Results revealed significantly less pain (P < 0.05) in the control group at 4 hours postoperatively. There were no significant differences in time to first analgesic request or supplementary analgesics required. We conclude that postincisional wound infiltration with 0.25% bupivacaine had no advantage compared with no wound infiltration in reducing postoperative pain scores or analgesic requirements after abdominal bysterectomy.