Efficacy of Tamsulosin 0.4 mg/day in Relieving Double-J Stent-related Symptoms: a Randomized Controlled Study
N Navanimitkul, บรรณกิจ โลจนาภิวัฒน์*
Division of Urology, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; E-mail: blojanap@mail.med.cmu.ac.th
บทคัดย่อ
This study evaluated the efficacy of tamsulosin in improving stent-related symptoms and quality of life in patients with in-dwelling double-J ureteral stents. A total of 42 patients (15 males and 27 females) with ureteral stent placement following ureteroscopy, ercutaneous nephrolithotomy or balloon dilatation, were prospectively randomized into two groups of 21 patients. Group I received 0.4 mg tamsulosin once daily for 4 weeks and group II was a non-placebo, non-treatment control. All patients completed the International Prostate Symptom Score (IPSS) and SF-36 questionnaires at 2 and 4 weeks post-operatively. The IPSS scores for irritative and obstructive symptoms were significantly lower in group I than group II at both 2 and 4 weeks. Among the eight domains of SF-36, role limitation due to physical health and bodily pain was significantly better in group I at 2 and 4 weeks. General health was also significantly better in group I at 2 weeks. Tamsulosin improved both urinary symptoms and quality of life without causing serious side-effects.
ที่มา
The Journal of International Medical Research ปี 2553, July-August ปีที่: 4 ฉบับที่ 38 หน้า 1436-1441
คำสำคัญ
Quality of life, Tamsulosin, α1-Adrenoceptor antagonist, Ureteral stent, Stent-related symptoms