Background: Non-ulcer dyspepsia (NUD) is a common disorder in clinical practice. The role of H. pylori eradication in patients with NUD remains controversial. The aim of this study was to evaluate the effect of omeprazole with antibiotics compared with omeprazole alone on symptom improvement in NUD patients with H. pylori infection.

Patients and Methods: This study was a double-blinded, randomized controlled study. Patients with NUD of 12 weeks or longer were randomized to receive omeprazole 20 mg twice daily, clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily for 14 days (treatment group) or omeprazole alone (placebo group). Esophagogastroduodenoscopy was performed in all patients. H. pylori infection was confirmed by positive rapid urease test and histopathological exam of antral mucosa. Symptom improvement was evaluated in terms of symptom score before treatment, 2 weeks, and 6 weeks after treatment.

Results: There were 36 patients in treatment group and 33 patients in placebo group. Symptom score after treatment was significantly lower than before treatment in both group (p <0.001) but there was no significant difference between treatment group and placebo group.

Conclusion: Omeprazole with antibiotics significantly reduced the overall symptom scores after 6 weeks of treatment compared to baseline in NUD patients but there was no significantly difference from omeprazole treatment alone.