Objective: To assess the sedative effect of foot reflexology on major depressive disorder patients. Methods: Of the 31 patients recruited in total, 16 were randomly assigned as controls and 15 were in the treatment (experimental) group. Results: The mean values of Chachoengsao Sleep Questionnaire (CSQ) were obtained from both groups before and after treatment and were significantly decreased from baseline. The CSQ scores in the experimental group were significantly lower than those of the control group on days 3, 4 and 5 of the study. Conclusion: Foot reflexology improves the quantity and quality of sleep in major depressive disorder patients.